Methadone Clinics San Juan TX
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Fertility Reproductive function in human males may be decreased by methadone treatment. Methadone is often administered to treat heroin addiction in pregnant women.
These factors, combined with sedation, have been linked to the causation of extensive dental damage.[31][32] Overdose[edit] Most people who have overdosed on methadone may show some of the following symptoms: Miosis (constricted pupils)[33] Vomiting[34] Hypoventilation (breathing that is too slow/shallow)[33] Drowsiness,[33] sleepiness, disorientation, sedation, unresponsiveness Skin that is cool, clammy (damp), and pale[33] Limp muscles,[33] trouble staying awake, nausea Unconsciousness[33] and coma[33] Death[34] The respiratory depression of an overdose can be treated with naloxone.[30] Naloxone is preferred to the newer, longer acting antagonist naltrexone. Some of the symptoms associated with an overdose include: Shallow breathing Confusion Cold skin Clammy skin Weak pulse Fainting Drowsiness Important Information Just the same as other narcotic medications, there are side effects of methadone. Deaths have been reported during conversion to methadone from chronic, high-dose treatment with other opioid agonists and during initiation of methadone treatment of addiction in subjects previously abusing high doses of other agonists . Matt Curley, PharmD Q: What are the side effects of taking methadone daily for pain long term?
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363 mg is a very high dose, but like the other answerer, it depends on the person, and why they're on that dose in the first place. The analgesic activity is shorter than the pharmacological half-life; dosing for pain control usually requires multiple doses per day normally dividing daily dosage for administration at 8 hour intervals.[52] The main metabolic pathway involves N-demethylation by CYP3A4 in the liver and intestine to give 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP).[1][53] This inactive product, as well as the inactive 2-ethyl-5-methyl-3,3- diphenyl-1-pyrroline (EMDP), produced by a second N-demethylation, are detectable in the urine of those taking methadone. In fact, injection of methadone does not result in a "rush" as with some other strong opioids such as morphine or hydromorphone, because its extraordinarily high volume of distribution causes it to diffuse into other tissues in the body, particularly fatty tissue; the peak concentration in the blood is achieved at roughly the same time, whether the drug is injected or ingested.[citation needed] Oral medication is usually preferable because it offers safety, simplicity and represents a step away from injection-based drug abuse in those recovering from addiction. You could be submitting a large number of automated requests to our search engine. Usual Adult Dose for Opiate Withdrawal For detoxification and maintenance of opioid dependence, the drug should be administered in accordance with the treatment standards cited in 42 CFR (Code of Feral Regulations) Section 8. If you miss your doses for longer than 3 days in a row, call your doctor for instructions.
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Many individuals don’t even know where to start looking when it comes to finding methadone clinics in their area. Head Injury And Increased Intracranial Pressure The respiratory depressant effects of opioids and their capacity to elevate cerebrospinal-fluid pressure may be markedly exaggerated in the presence of head injury, other intracranial lesions or a pre-existing increase in intracranial pressure.
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Initial Administration The initial methadone dose should be carefully titrated to the individual. Because methadone causes constipation, taking antidiarrheal medications such as diphenoxylate (Lomotil) and loperamide (Imodium) along with methadone can result in severe constipation. In severe overdosage, particularly by the intravenous route, apnea, circulatory collapse, cardiac arrest, and death may occur. Most cases involve patients being treated for pain with large, multiple daily doses of methadone, although cases have been reported in patients receiving doses commonly used for maintenance treatment of opioid addiction. The bioavailability and elimination half-life of methadone are subject to substantial interindividual variability. If you take methadone for pain: Take the missed dose as soon as you remember, then take your next dose 8 to 12 hours later. The medication is administered in liquid or tablet form on a daily basis.
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