Methadone Clinics Lake Jackson TX
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Some data also indicate that methadone acts as an antagonist at the N-methyl-D-aspartate (NMDA) receptor. This should be considered when prescribing or dispensing methadone hydrochloride oral concentrate in situations where the clinician is concerned about an increased risk of misuse, abuse, or diversion.
In plasma, methadone is predominantly bound to α1 -acid glycoprotein (85% to 90%). Cytochrome P450 Inducers Methadone-maintained patients beginning treatment with CYP3A4 inducers should be monitored for evidence of withdrawal effects and methadone dose should be adjusted accordingly. Your doctor is best able to evaluate your medical condition, including side effects, and make recommendations for managing them based on your specific circumstances. Many people have successfully overcome their addiction by using methadone during detoxification and maintenance programs.
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Initial doses should be lower for patients whose tolerance is expected to be low at treatment entry. John's wort preparations can increase the liver's ability to metabolize (eliminate) methadone and reduce its blood concentration which could result in withdrawal side effects, while drugs such as erythromycin (E-Mycin, Eryc, Ery-Tab), clarithromycin (Biaxin, Biaxin XL), ketoconazole (Nizoral), and itraconazole (Sporanox) can decrease the liver's ability to metabolize methadone thereby increasing the side effects of this drug. Anti-retroviral agents including abacavir (Ziagen), amprenavir (Agenerase), efavirenz (Sustiva), nelfinavir (Viracept), Nevirapine (Viramune, Viramune XR), Ritonavir (Norvir), and lopinavir/ ritonavir (Kaletra) have been shown to decreased the blood levels of methadone making it necessary to adjust the dose of methadone to prevent narcotic withdrawal effects. Some drugs that slow the heart rate for example, dofetilide (Tikosyn), procainamide (Pronestyl, Procan-SR), quinidine, and sotalol (Betapace), as well as laxatives and diuretics that cause low magnesium or low potassium in the body, for example, furosemide (Lasix), can cause rare serious and fatal irregular heartbeats.Methadone Dosage Medically reviewed on February 13, 2018.
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It can't go down: "wrong pipe" without causing violent coughing and retching. Methadone can cause slow or shallow breathing and dangerous changes in heartbeat that may not be felt by the patient." The advisory urged that physicians use caution when prescribing methadone to people who are not used to the drug and that people take the drug exactly as directed.[23] Adverse effects of methadone include:[citation needed] Sedation Diarrhea[24] or constipation[24][25] Flushing[25] Perspiration[25] and sweating[25] Heat intolerance Dizziness[24][26][27] or fainting[24][26][27] Weakness[25] Chronic fatigue, sleepiness[25] and exhaustion Sleep problems such as drowsiness,[24] trouble falling asleep (Insomnia),[25][26] and trouble staying asleep[25] Constricted pupils Dry mouth[24][25] Nausea[24][25] and vomiting[24][25] Low blood pressure Hallucinations[24][26] or confusion[24][26] Headache[25] Heart problems such as chest pain[24][26] or fast/pounding heartbeat[24][26][27] Abnormal heart rhythms[27][28] Respiratory problems such as trouble breathing,[24][26] slow or shallow breathing (hypoventilation),[24][26] light-headedness,[24][26][27] or fainting[24][26] Loss of appetite,[24][25] and in extreme cases anorexia Weight gain[25] Memory loss Stomach pains[25] Itching Difficulty urinating[25] Swelling of the hands, arms, feet, and legs[25] Feeling restless[24] or agitated Mood changes,[25] euphoria, disorientation Nervousness[24] or anxiety[24][26] Blurred vision[25] Decreased libido,[24][25] missed menstrual periods,[25] difficulty in reaching orgasm,[24] or impotence[24][25] Skin rash Seizures Central sleep apnea Withdrawal symptoms[edit] Physical symptoms[citation needed] Lightheadedness[29] Tearing of the eyes[29][30] Mydriasis (dilated pupils)[29] Photophobia (sensitivity to light) Hyperventilation syndrome (breathing that is too fast/deep) Runny nose[30] Yawning Sneezing[30] Nausea,[29][30] vomiting,[29][30] and diarrhea[29] Fever[30] Sweating[29] Chills[30] Tremors[29][30] Akathisia (restlessness) Tachycardia (fast heartbeat)[30] Aches[29] and pains, often in the joints or legs Elevated pain sensitivity Blood pressure that is too high (hypertension, may cause stroke) Cognitive symptoms[citation needed] Suicidal ideation Susceptibility to cravings[29] Depression[29] Spontaneous orgasm Prolonged insomnia Delirium Auditory hallucinations Visual hallucinations Increased perception of odors (olfaction), real or imagined Marked decrease or increase in sex drive Agitation Anxiety[29] Panic disorder Nervousness[29] Paranoia Delusions Apathy Anorexia (symptom) Methadone withdrawal symptoms are reported as being significantly more protracted than withdrawal from opioids with shorter half-lives. The private clinics are more expensive to attend but usually have either a short or no waiting list. A medical examination is given prior to administration of the methadone, and new patients are often tested for certain conditions which are known to be prevalent in addict populations, such as HIV, hepatitis, and tuberculosis.
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Stringent regulations at the Christchurch programme force consumers to provide at least three clean urine samples before being accepted - a practice not used anywhere else in New Zealand and "quite out of keeping" with national guidelines. You may still have methadone residuals in your body after the pain relieving effect of the medication wears off. My clinic even warned me about certain things, cold remedies being one of them. There have been rare cases of sedation and respiratory depression in infants exposed to methadone through breast milk. A: Dolophine (methadone) is a medication used to treat pain and to help treat opiate addiction. The private clinics are more expensive to attend but usually have either a short or no waiting list. Methadone is available in traditional pill, sublingual tablet, and two different formulations designed for the person to drink. Opiate addiction can lead to a number of consequences include health related problems, legal troubles, financial distress and potentially death. Patients developing QT prolongation while on methadone treatment should be evaluated for the presence of modifiable risk factors, such as concomitant medications with cardiac effects, drugs which might cause electrolyte abnormalities and drugs which might act as inhibitors of methadone metabolism. Lowest, Average and Highest Dosage The maximum safe maintenance dosage is between 60-120 mg.
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