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If cessation of therapy is indicated, it may be appropriate to taper the methadone dose, rather than abruptly discontinue it, due to the risk of precipitating withdrawal symptoms. Under the conditions of the assay, there was no clear evidence for a treatmentrelated increase in the incidence of neoplasms in either male or female rats. Not having to deal with the clinic beauracreacy, also lifted my spirits for sure. They are there to keep you on this drug that rots away at your mind and body, and they do it well. LIFE-THREATENING RESPIRATORY DEPRESSION: Serious, life-threatening, or fatal respiratory depression may occur.

Methadone addiction can develop through illicit use, which is any use without a prescription, or by using the drug improperly (e.g., taking more than prescribed or combining the drug with other substances of abuse). Methadone clinics in the United States operate under close federal observation and regulation.

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It does a great job keeping you on baseline, without the highs of getting high and lows of not. If you try to warm (cook) this with water it will become a gelantine substans unusable for injecting. Methadone may be habit-forming, meaning that it is possible to become physically or mentally dependent on the drug.

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The ingredients could vary by manufacturer, and other things may be added to it depending where it is dispensed Can methadone ten mg tablets be dissolved in liquid? Methadone is used as a pain reliever and as part of drug addiction detoxification and maintenance programs. Despite methadone's much longer duration of action compared to either heroin and other shorter-acting agonists, and the need for repeat doses of the antagonist naloxone, it is still used for overdose therapy. Patients and caregivers should be instructed to keep methadone in a secure place out of the reach of children and to discard unused methadone in such a way that individuals other than the patient for whom it was originally prescribed will not come in contact with the drug. The drug, which had been developed a decade before by German scientists Max Bockmühl and Gustav Ehrhart, was lauded as an effective and less addictive substitute for painkillers like morphine and opiates.

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This drug should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Information is right at your fingertips, and any other details you need can be discovered through contacting the clinic itself, another action made easier by the directory. To help a Methadone addict, call our 24/7 hotline at 1-888-744-0069 for more information. Methadone can cause slow or shallow breathing and dangerous changes in heartbeat that may not be felt by the patient." The advisory urged that physicians use caution when prescribing methadone to people who are not used to the drug and that people take the drug exactly as directed.[23] Adverse effects of methadone include:[citation needed] Sedation Diarrhea[24] or constipation[24][25] Flushing[25] Perspiration[25] and sweating[25] Heat intolerance Dizziness[24][26][27] or fainting[24][26][27] Weakness[25] Chronic fatigue, sleepiness[25] and exhaustion Sleep problems such as drowsiness,[24] trouble falling asleep (Insomnia),[25][26] and trouble staying asleep[25] Constricted pupils Dry mouth[24][25] Nausea[24][25] and vomiting[24][25] Low blood pressure Hallucinations[24][26] or confusion[24][26] Headache[25] Heart problems such as chest pain[24][26] or fast/pounding heartbeat[24][26][27] Abnormal heart rhythms[27][28] Respiratory problems such as trouble breathing,[24][26] slow or shallow breathing (hypoventilation),[24][26] light-headedness,[24][26][27] or fainting[24][26] Loss of appetite,[24][25] and in extreme cases anorexia Weight gain[25] Memory loss Stomach pains[25] Itching Difficulty urinating[25] Swelling of the hands, arms, feet, and legs[25] Feeling restless[24] or agitated Mood changes,[25] euphoria, disorientation Nervousness[24] or anxiety[24][26] Blurred vision[25] Decreased libido,[24][25] missed menstrual periods,[25] difficulty in reaching orgasm,[24] or impotence[24][25] Skin rash Seizures Central sleep apnea Withdrawal symptoms[edit] Physical symptoms[citation needed] Lightheadedness[29] Tearing of the eyes[29][30] Mydriasis (dilated pupils)[29] Photophobia (sensitivity to light) Hyperventilation syndrome (breathing that is too fast/deep) Runny nose[30] Yawning Sneezing[30] Nausea,[29][30] vomiting,[29][30] and diarrhea[29] Fever[30] Sweating[29] Chills[30] Tremors[29][30] Akathisia (restlessness) Tachycardia (fast heartbeat)[30] Aches[29] and pains, often in the joints or legs Elevated pain sensitivity Blood pressure that is too high (hypertension, may cause stroke) Cognitive symptoms[citation needed] Suicidal ideation Susceptibility to cravings[29] Depression[29] Spontaneous orgasm Prolonged insomnia Delirium Auditory hallucinations Visual hallucinations Increased perception of odors (olfaction), real or imagined Marked decrease or increase in sex drive Agitation Anxiety[29] Panic disorder Nervousness[29] Paranoia Delusions Apathy Anorexia (symptom) Methadone withdrawal symptoms are reported as being significantly more protracted than withdrawal from opioids with shorter half-lives. Food and Drug Administration by visiting www.fda.gov/medwatch or by calling 1-800-FDA-1088.

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