Monitoring: -Monitor closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy and following dose increases. -Monitor regularly for the development of addiction, abuse, and misuse. -Monitor for signs of hypotension upon initiating therapy and following dose increases, especially those whose blood pressure is compromised. -Monitor for signs and symptoms of QT prolongation, if used in at-risk patients or concomitantly with drugs that prolong the QT interval, consider monitoring ECG and electrolytes at baseline and periodically during treatment. -During the induction phase as patients are being withdrawn from illicit opioids, monitor of opioid withdrawal symptoms such as lacrimation, rhinorrhea, sneezing, yawning, excessive perspiration, goose-flesh, fever, chilling, irritability, weakness, anxiety, depression, dilated pupils, tremors, tachycardia, abdominal cramps, body aches, involuntary twitching, anorexia, nausea, vomiting, diarrhea, intestinal spasms. Food and Drug Administration issued a Public Health Advisory about methadone titled "Methadone Use for Pain Control May Result in Death and Life-Threatening Changes in Breathing and Heart Beat". These side effects may go away during treatment as your body adjusts to the medicine.
It can also cause side effects that impair your thinking and reactions. XML that has been specially designed to handle such requests. Your doctor should monitor you closely during this time. Cytochrome P450 Inhibitors Since the metabolism of methadone is mediated primarily by CYP3A4 isozyme, coadministration of drugs that inhibit CYP3A4 activity may cause decreased clearance of methadone. Mallinckrodt received approval for their branded generic, Methadose, on April 15, 1993 for their 5 mg and 10 mg Methadose Tablets.
Others Monoamine Oxidase (MAO) Inhibitors Therapeutic doses of meperidine have precipitated severe reactions in patients concurrently receiving monoamine oxidase inhibitors or those who have received such agents within 14 days. In 2009, the CDC found that over 4 million people were prescribed methadone by a physician. When using naloxone, the naloxone will be quickly eliminated and the withdrawal will be short lived.
Indications & Dosage INDICATIONS For detoxification treatment of opioid addiction (heroin or other morphine-like drugs). Methadone may cause a life-threatening heart rhythm disorder. Therefore, drugs administered concomitantly with methadone should be evaluated for interaction potential; clinicians are advised to evaluate individual response to drug therapy before making a dosage adjustment. A: Methadone is in a drug class called opiate or narcotic analgesics.
Liver Dose Adjustments Hepatic impairment: Start at the low end of the dosing range and titrate slowly; closely monitor for signs of respiratory and CNS depression. Some clinics also offer short- or long-term detoxification services to their patients using methadone. Track monthly urine and lab tests, update treatment plans every ninety days, complete progress notes in a timely manner and perform medically required services on schedule and within the time frame prescribed by state and federal agencies. CONTRAINDICATIONS Methadone hydrochloride oral concentrate is contraindicated in patients with a known hypersensitivity to methadone hydrochloride or any other ingredient in methadone hydrochloride oral concentrate. Furthermore, opioids produce effects which may obscure the clinical course of patients with head injuries. Read More Hi, I just want to echo what mrmichael said about methadone clinics, that some are good and some not as good. It might be worth checking your computer for viruses with an antivirus utility such as CureIt from «Dr.
Click Here for More Information