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Other adverse reactions include the following: (listed alphabetically under each subsection) Body as a Whole: asthenia (weakness), edema, headache Cardiovascular:(also see WARNINGS: Cardiac Conduction Effects): arrhythmias, bigeminal rhythms, bradycardia, cardiomyopathy, ECG abnormalities, extrasystoles, flushing, heart failure, hypotension, palpitations, phlebitis, QT interval prolongation, syncope, T-wave inversion, tachycardia, torsade de pointes, ventricular fibrillation, ventricular tachycardia Digestive: abdominal pain, anorexia, biliary tract spasm, constipation, dry mouth, glossitis Hematologic and Lymphatic: reversible thrombocytopenia has been described in opioid addicts with chronic hepatitis Metabolic and Nutritional: hypokalemia, hypomagnesemia, weight gain Nervous: agitation, confusion, disorientation, dysphoria, euphoria, insomnia, seizures Respiratory: pulmonary edema, respiratory depression (see WARNINGS: Respiratory Depression) Skin and Appendages: pruritis, urticaria, other skin rashes, and rarely, hemorrhagic urticaria Special Senses: hallucinations, visual disturbances Urogenital: amenorrhea, antidiuretic effect, reduced libido and/or potency, urinary retention or hesitancy Maintenance on a Stabilized Dose During prolonged administration of methadone, as in a methadone maintenance treatment program, there is usually a gradual, yet progressive, disappearance of side effects over a period of several weeks. Storage requirements: -Protect from light General: -Acidification of the urine may enhance urinary excretion of this drug. -Treatment with this drug should be managed by physicians with suitable experience. -Because of the greater risk of overdose and death with this long-acting opioid, when used for pain management, this drug should only be used in patients for whom alternative treatment options are ineffective, not tolerated, or would otherwise be inadequate to provide sufficient pain management. -For patients receiving other opioid analgesics and switching to this drug, it is safer to underestimate a patient's 24-hour oral requirement and provide rescue medication than overestimate and manage an adverse reaction; there is substantial inter-patient variation in the relative potency of different opioid drugs that conversion tables are not able to capture. -During chronic therapy, periodically reassess the continued need for opioid analgesics. Dosing of methadone is usually patient specific so consult with your doctor about your particular situation. Although, methadone, as a drug, is very strong and very long lasting so I do not recommend taking methadone without contacting a physician.

Many substances can also induce, inhibit or compete with these enzymes further affecting (sometimes dangerously) methadone half-life. Proper assessment of the patient, proper prescribing practices, periodic re-evaluation of therapy, and proper dispensing and storage are appropriate measures that help to limit abuse of opioid drugs. Methadone use is usually compatible with breastfeeding. Methadone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription. If you take methadone for drug addiction: Take your missed dose the next day at the regular time. Frequent monitoring for adverse events and toxicity related to methadone is recommended during coadministration.

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The dosage may need to be increased or the dosing interval decreased in pregnant patients receiving methadone. (See PRECAUTIONS : Pregnancy, Labor and Delivery, and DOSAGE AND ADMINISTRATION.) Renal Impairment Methadone pharmacokinetics have not been extensively evaluated in patients with renal insufficiency. Long-Term Side Effects Methadone addiction is a very real issue for many people. It’s best to start with the area closest to you and then expand if need be. Another thing is to demand liquid methadone because if you ever want to try a detox you can do it slowly.

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Read More well hi its been 4 days no methadone wds were mild for me until I quit that's when your body says were the hell is the liquid, well I relapse to tyn 4s it help me deal with the wds only temp. tillthe methadone leaves, it should be any day I would think, I don't want to get hooked back up on opiates, man made or the real deal, but people go to subs. its a lot stronger and harder to get off then codine, I will make it got off the horrible methadone I surely can get off the tyn. Stigmas surrounding these clinics, however, may still prevent them from certain communities. Read More » Selecting a Top Comprehensive Treatment Center Selecting a top methadone treatment clinic that best meets your specific needs is one of the most important steps on the path back from addiction. Methadone also acted as a potent, noncompetitive α3β4 neuronal nicotinic acetylcholine receptor antagonist in rat receptors, expressed in human embryonic kidney cell lines.[45] [edit] Methadone has a slow metabolism and very high fat solubility, making it longer lasting than morphine-based drugs.

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Then, over time, tolerance increases with the new opioid, requiring higher doses. Methadone prevents withdrawal symptoms from happening in people who were addicted to opiate medications. The highest dose of Methadone that should be used for replacement therapy when treating severe opioid addiction is 160 mg. Read More Do any of you know if phsyciatrist are qualified with addiction?? It also depends on how long the person has been using the drug(s) and the method (i.e. oral, inhaled, or injected).[16][17] In addition, enrollment in methadone maintenance has the potential to reduce the transmission of infectious diseases associated with opiate injection, such as hepatitis B and C, and/or HIV.[16] The principal goals of methadone maintenance are to relieve opioid cravings, suppress the abstinence syndrome, and block the euphoric effects associated with opioids. What I don't understand is why anybody would even think of changing your medication regime when you seemed to be doing fine for years and years on the same dose!!! According to a report published by the Washington University in St. Read More Why is 150 methadone liquid not stopping my cravings and I take up to 300 on my take home day, what's going on with me? CERTIFIED TREATMENT PROGRAMS SHALL DISPENSE AND USE METHADONE IN ORAL FORM ONLY AND ACCORDING TO THE TREATMENT REQUIREMENTS STIPULATED IN THE FEDERAL OPIOID TREATMENT STANDARDS (42 CFR 8. Methadone clinics are now operating in OTP settings of stand-alone clinics, hospitals, and health care centers that may be publicly funded to reduce the costs of treatments to the individual. These include: Abnormally low blood pressure Feeling faint Slow heartbeat Collapsed lung Decrease in lung function Fast heartbeat Trouble breathing Feeling of confusion If you are taking methadone and experiencing any side effects outside the norm, contact your medical professional immediately. Hypotensive Effect The administration of methadone may result in severe hypotension in patients whose ability to maintain normal blood pressure is compromised (e.g., severe volume depletion). A common term for the type of treatment at a methadone clinic is "replacement therapy".

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