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As with any prescription medication, it is not suggested that you miss a dose. Very dangerous if no opiate tolerance and a need for it!

The dose of methadone can be decreased on a daily basis or at 2-day intervals, but the amount of intake should remain sufficient to keep withdrawal symptoms at a tolerable level. Many physicians and OTP hubs are available to provide medical maintenance where up to a month’s supply can be prescribed for those transferring from a formal methadone maintenance program. The use of heroin and the illicit use of prescription opiates are also associated with erectile dysfunction.

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The usual precautions should be observed and the possibility of respiratory depression requires added vigilance. Upon discontinuation of phenytoin, the incidence of withdrawal symptoms decreased and methadone exposure increased to a level comparable to that prior to phenytoin administration. It's uncommon for tablets to be crushed and injected, but even the injectable solution can cause problems, especially if the same needle is used with multiple people or for multiple doses.

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Other putative mechanisms of methadone-related tooth decay include craving for carbohydrates related to opioids, poor dental care, and general decrease in personal hygiene. Increased plasma concentrations of methadone have been associated with toxicity including QT prolongation. People who metabolize methadone rapidly, on the other hand, may require twice daily dosing to obtain sufficient symptom alleviation while avoiding excessive peaks and troughs in their blood concentrations and associated effects.[50] This can also allow lower total doses in some such people.

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HOW SUPPLIED Methadone Hydrochloride Oral Concentrate USP, (Dye-Free, Sugar-Free, Unflavored) 10 mg per mL is supplied as a clear, colorless, unflavored solution. The highest MG of methadone that I have seen people successfully walk off and stay off methadone is around 15mg's. Dolophine (methadone)." Lilly, Eli and Company, Indianapolis, IN. While not restricted to adults, this treatment method is generally not considered for people under the age of 18. There is an entirely separate 40mg Methadose pill, but the DEA has recently restricted it to opiate abuse treatment centers only. Methadone is slowly eliminated from the body, so you may not have experienced any side effects at the beginning of the reduction of this medication. There is also a website www.suboxone.com where you can find a lot of information. While generally considered successful as a treatment method, the use of this maintenance treatment is often viewed as controversial. Methadone clinics are only for recovering addicts from opioids. Others advocate for other, safer drugs like buprenorphine, an opioid antagonist that will bind to receptors in the brain (providing pain relief) without activating them (eliminating any potential for a high). A 2014 study published in the Public Library of Science found that methadone treatment not only helped individuals stay sober; it ultimately reduced the rates of HIV and hepatitis C in Xi’an, China. Step One: Find Methadone Clinics by State To find Methadone clinics in your state, do some research online.

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